Yes, we did remotely access the computer and found a few issues. First, it was a 2006 installation with a 2008 version of medialab.exe. That was really odd (as if the newest exe was simply dropped into a v2006 ML folder). We uninstalled and reinstalled and had the same issue with the path access error. Turned out that the comport.txt file was causing the error. If we removed that one file, then everything worked fine. I noticed that the com1 port was set to 9600 baud but that the hardware she was using communicating at 19200 baud. We played around with this but I eventually ran out of ideas--aside from trying it on a different computer which I think she said may have worked. In any case, it seems related to the special hardware being accessed via the comport.txt file.